Food-derived Bioactive Peptides as potential GPCR-binding ligands
OVERVIEW
Anaerobic bacteria, renowned for their role as producers of bioactive molecules sourced from raw biomaterials, particularly stand out for generating bioactive peptides. These peptides serve as ligands for various G protein-coupled receptors (GPCRs), often with health-promoting effects. Leveraging a peptidomic approach, our laboratory systematically seeks and predicts bioactive peptides derived from (gut) microbiota, striving to optimize their production through the bacterial conversion of challenging protein biomass such as keratin, collagen, soybean, and green tea. Additionally, our investigative toolkit includes mass spectrometry and meta-proteomics to comprehensively explore all interactions within the biological system. The findings from these studies hold promising applications in the fields of cosmeceuticals, nutraceuticals, and pharmaceuticals.
RESEARCH TOPICS
- Microbial bioactive peptides from animal proteins (fish collagen, poultry & antler keratin)- Microbial bioactive peptides from plant proteins (soybean, green tea)
